Aiming for 130 to reach longevity escape velocity

Disclaimer: This longevity escape velocity survival plan should not be taken as medical advice. It describes my personal strategies and tools for staving off aging and death. I base my plan solely on scientific research and will do my best to quote sources consistently. All life is precious and I wish that everyone could keep theirs. This plan is a work in progress and will be modified as new knowledge comes to light. You are welcome along for the ride at your own discretion. You are also very welcome to suggest corrections or improvements to the plan.

How I plan to reach 130 it and why it will work

The longest authenticated human lifespan to date is 122 years (Jeanne Louise Calment). Even if she was purposely trying to live as long as possible, she didn’t have the resources that we have today. With constantly increasing knowledge about healthy living, good access to healthcare, scientific advances, new anti aging therapies (existing and upcoming) we can realistically aim for the currently living generations to reach at least 130 years – with active effort.

With the current pace of advances in science and technology (epigenetic reprogramming of cells, gene therapies, artificial intelligence), it’s beginning to look very likely that humanity will reach the longevity escape velocity (biological immortality) within the next 20-40 years – lab mice even sooner. If history is any indication, then every passing decade brings new radical therapies which were previously thought to be impossible.

The purpose of this survival plan is to help us reach at least 130 years in the best possible shape, by utilizing all the knowledge and technologies presently available. While we aim for 130, this puts us well within the range for the anticipated longevity escape velocity. In essence, aiming for 130 is baby steps towards biological immortality.

Let’s however act as if the longevity escape velocity will never happen unless we do something, and then do everything we can to reach it. It doesn’t matter who you are and what you do – if you would like to stay alive we are on the same team, so let’s contribute to the best of our abilities. People on a mission can bring change rapidly. Everyone has talents, we just have to find ways to direct them towards this common goal. We might want to postpone hobbies and other non-essential work for later, when our time stops running out. At the moment our period of adequate mental energy and clarity is limited and expiring. If we are going to do something, now is the time.

I suggest you take a look at the section why we age before you proceed. If you are serious about health and longevity you should understand what is going on with our bodies.

The 130 years survival plan

At the moment our existing tools are relatively primitive for what we need them to do, but they are all we have and will do fine for now. Yes, there are some more advanced, experimental tools in the works, which are being tested on animals to determine if they are viable for us. Personally I’m not yet in such a pressing need, to risk testing them on myself. Your body might be further along on the damage scale so your situation and reasoning could be different.

The longevity escape velocity survival plan can currently be divided into

  1. Avoid speeding up the aging process
  2. Employ methods that slow down the aging process
  3. Contribute to humanity’s drive towards reaching the longevity escape velocity

1. How to avoid speeding up the aging process

Our cells, organs and the entire body are highly adaptive to the environment and internal circumstances. Everything we do or experience causes changes on a cellular level. Some changes are instantly noticeable (chills, emotions, inflammation, feeling energetic, pain, etc) while the more subtle ones become noticeable when they build up (any system dysfunction or improved function). Our systems try to always keep us in an optimal state considering all circumstances. For example, if your everyday life involves rock climbing your muscles will strengthen and your brain will perfect the skill and agility for this task. After a while, such a person’s physique will be visibly different when compared to someone with a completely different lifestyle. Our cells come with the blueprint (DNA) for everything that they could be required to do. Being able to quickly find the appropriate sections of the blueprint and correctly following through is governed by the epigenome – a collective name for proteins which take care of the DNA and control expression of genes.

Our cells take instructions from the epigenome which takes instructions from the circumstances we put ourselves in. We can thus purposefully design the circumstances to achieve the desired changes on a cellular level. In other words, do what is beneficial and avoid doing what is harmful to the aging process. One such example where we can see the consequences of our actions on a cellular level is bodybuilding. The person makes his body believe, that the environment is extremely harsh and surviving involves moving of heavy objects. The body gradually adapts by strengthening bones, muscles and various mental coping mechanisms to get the person to persist. To other people around him, the bodybuilder then looks like an alien from a world where gravity is much stronger and life more difficult.

For this section of the survival plan the goal is dual. To figure out:
a) which circumstances we need to avoid in order to reduce the speed of damage accumulation to our tissues
b) which circumstances we need to put ourselves into, to induce and increase our capacity for damage repair

These are some of the things we should avoid:

2. Technological prevention of aging (supplements, adjuvants, therapies)

DNA Damage Telomere shortening Epigenetic alterations Loss of proteostasis Deregulated nutrient sensing Mitochondrial dysfunction Cellular senescence Stem cell exhaustion Altered intercellular communication Total score
Sources:
Metformin 0 0 0 0 0 0 0 0 0 0
Resveratrol 0 0 0 0 0 0 0 0 0 0
Pterostilbene 0 0 0 0 0 0 0 0 0 0
Nicotinamide Mononucleotide (NMN) 0 0 0 0 0 0 0 0 0 0
Nicotinamide Riboside (NR) 0 0 0 0 0 0 0 0 0 0
Astaxanthin 0 0 0 0 0 0 0 0 0 0
Curcumin 0 0 0 0 0 0 0 0 0 0
Alpha Lipoic Acid 0 0 0 0 0 0 0 0 0 0
Quercetin 0 0 0 0 0 0 0 0 0 0
Cycloestragenol 0 0 0 0 0 0 0 0 0 0
Melatonin 0 0 0 0 0 0 0 0 0 0
Human Growth Hormone 0 0 0 0 0 0 0 0 0 0
Semax 0 0 0 0 0 0 0 0 0 0
Ostarine 0 0 0 0 0 0 0 0 0 0

3. Contribute to humanity’s drive to reach the longevity escape velocity

Contributing to anti aging research

What the future holds

The complexity and interconnectedness of our biochemistry is such, that every cellular process causes cascading, domino effects (desired and undesired) on other processes. A solution to aging would require weeding out the undesired effects while keeping the desired ones. Our brains are capable of figuring out most of the required details, however we are not very good at simultaneously considering thousands of interconnected factors. We can probably come very close to achieving biological immortality all by ourselves, but maybe we won’t have to. The Artificial Intelligence (AI) which the humanity has been developing for the past few decades will be perfectly suitable for this task and is getting better every year. Our part is to figure out the necessary details and feed them to the AI. Soon enough it will be capable to piece them together and create the ultimate anti aging therapy and DNA upgrade for a permanent solution.

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